期刊目錄列表 - 31～41期(1986-1996) - 第三十三期 (1988)
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硫酸甲酯新斯狄明之合成
作者:龔自琪、姜宏哲(國立臺灣師範大學理學院化學研究所)
摘要：
本合成法以Bobranskii法作藍本以二甲氨基苯為出發並經過五個合成步驟合成硫酸甲酯新斯狄明。Bobranskii法中之由間二甲基氨基酚合成新斯狄明步驟部分經改良產率由原法之57％提高到92％。
《詳全文》
Journal directory listing - Volume 31-41 (1986-1996) - Volume 33 (1988)
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Synthesis of Neostigmine Methylsulfate
Author: Hung-Cheh Chiang, Tzu-Chi Kung
Abstract：
Neostigmine methlsulfate is a parasympathetic drug. After checking and improving the synthetic methods of various paper and patents, our laboratory has now found a valid and economic sythetic method, the modified Boracskii and Gellet method. The synthetic step of m-dimthylaminophenol to neostigmine in Bobranskii method is improved and the yield is increased from 51% to 92%.